Cissus Joint and Tendon SupportCissus Joint and Tendon Support Called the Bone Setter in some cultures, Cissus quadrangularis is a traditional Indian medicine now used by modern athletes to treat bone and joint injuries, fight inflammation, and reduce joint pain. Unlike the garbage traditionally peddled by supplement companies to treat joint pain (like shark cartilage, glucosamine, and chondroitin), cissus actually works, and has been shown to do so in multiple clinical studies.